Spravato Nasal Ketamine Treatment for Depression
If you’re exploring ketamine therapy in Savannah, GA, Daniel Perry MD offers a modern, clinically proven option called Spravato, a prescription nasal form of ketamine for adults with treatment-resistant depression or major depressive disorder with suicidal thoughts.
Spravato is administered in-office under medical supervision and offers many of the same benefits as ketamine infusion therapy, without the need for IVs or long recovery periods.

Spravato (esketamine) is a nasal spray form of ketamine that works rapidly to relieve symptoms of depression. It is FDA-approved for individuals who haven’t responded to traditional antidepressants or who experience suicidal ideation.
Spravato is administered in a calm, supervised setting during scheduled office visits. Each session includes monitoring before and after your dose to ensure safety and comfort.
Unlike IV ketamine infusions, which are usually not covered by insurance and require self-pay, Spravato is FDA-approved and covered by many major insurance plans, meaning most patients pay little to nothing out of pocket.
Ketamine therapy works differently from conventional antidepressants. Instead of acting on serotonin, Spravato targets glutamate, a neurotransmitter that helps regulate brain plasticity and mood. This unique mechanism can create new connections in the brain, helping to reset mood and reduce symptoms of chronic depression.
Many patients begin noticing improvements after just a few sessions, even when previous medications have failed.
Spravato may be appropriate for adults who:
A full psychiatric evaluation is required before treatment begins to determine eligibility and ensure safe outcomes.
Spravato may not be right for individuals who:
We carefully assess each patient to determine the best and safest treatment options.
One of the biggest advantages of Spravato treatment is affordability.
Unlike IV ketamine infusions, which are typically not covered by insurance and often require patients to pay hundreds of dollars per session out of pocket, Spravato is FDA-approved and covered by many major insurance plans.
This means that most eligible patients pay little to nothing out of pocket, depending on their coverage.
While coverage and copays vary by plan, many patients find Spravato to be significantly more affordable than IV ketamine infusions due to:
Our office assists patients with insurance verification and prior authorization to help clarify expected costs before treatment begins.
While both Spravato and IV ketamine are based on the same compound family and are used for treatment-resistant depression, there are key differences in how they’re delivered and managed.
Spravato is a nasal spray form of ketamine (esketamine) that is FDA-approved and administered under psychiatrist supervision during a scheduled office visit. It follows a strict treatment protocol with built-in patient monitoring before and after each dose.
IV ketamine, on the other hand, is typically offered by wellness clinics or infusion centers and is administered through an intravenous drip. It is considered an off-label use and protocols may vary between providers. Monitoring also depends on the clinic.
Both are used to help individuals who have not responded to traditional antidepressants, but Spravato offers a regulated, clinician-directed approach designed for long-term management.
Spravato is generally well-tolerated, but like all medical treatments, it may have side effects. These can include:
All sessions include post-dose monitoring to ensure your safety and wellbeing.
One of the most common questions we hear is:
“Does ketamine therapy get you high?”
While some patients experience brief dissociation or altered perception during treatment, Spravato is not recreational. These effects are mild, short-lived, and medically supervised. Most patients describe the experience as neutral or calming, not euphoric.
If you’re struggling with depression and looking for a modern, effective option, consider ketamine therapy with Spravato in Savannah, GA. Relief is possible even if other treatments have failed.
📞 Call 912-513-2888
📅 Or schedule your consultation online
Disclaimer: This page is for informational purposes only and does not constitute medical advice. Always consult a licensed provider before beginning any treatment.
